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生物物理所等在傷口敷料性能提升方面取得進展

文章來源:生物物理研究所   發布時間:2019-03-22  【字號:     】  

  3月12日,Biomaterials 期刊發表了中國科學院生物物理研究所研究員秦燕課題組與北京科技大學教授溫永強的合作研究成果,題為Layered Nanofiber Sponge with an Improved Capacity for Promoting Blood Coagulation and Wound Healing。該項工作改變了傷口敷料的傳統結構,對止血和組織重建產生了重要的影響。在具有層狀結構的三維納米纖維海綿的治療下傷口能夠快速止血并且再生皮膚組織具有較小的瘢痕,有效地促進了傷口愈合。

  在日常生活中,有效控制出血和促進傷口愈合是非常重要的,甚至可以挽救生命。然而,具有結構和功能缺陷的傳統傷口敷料在控制出血和促進功能性組織再生方面能力相對較弱。在該研究中,利用靜電紡絲技術將殼聚糖和PVA制備成二維納米纖維膜后,再將二維納米纖維膜進行擴展獲得三維(3D)層狀納米纖維海綿。這種海綿具有分層的納米纖維結構,增加了海綿和血細胞之間的界面相互作用,加速了止血。通過結構的微調,3D納米纖維海綿獲得了有利于傷口愈合的性質,例如良好的彈性、高的透氣性和液體吸收能力。3D納米纖維海綿具有的高度可壓縮性和耐疲勞性可為深部傷口提供填塞,并且創建了良好的3D動態微環境以調節細胞行為。進一步的研究表明,層狀納米纖維結構可以在早期修復階段促進功能性真皮的再生和脂肪細胞的恢復。使用具有全層皮膚缺陷的模型小鼠的實驗表明,具有層狀結構的納米纖維海綿可以有效地加速傷口愈合并減少瘢痕形成。綜上所述,層狀結構的三維納米纖維海綿具有優異的止血和促愈合性能并且易于生產,這為傷口敷料帶來很大臨床應用潛力。

  該研究得到中國重點研發計劃項目、國家自然科學基金、北京市自然科學基金以及中科院重點部署項目的資助。

  文章鏈接

 

圖示:3D CS / PVA納米纖維海綿在全層皮膚缺損小鼠模型中的填塞效應




(責任編輯:葉瑞優)

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